Respiratory Research
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  ReviewLung surfactant in subacute pulmonary diseaseGehan Devendra1 and Roger G Spragg2  1
University of California, San Diego, California, USA 2
San Diego Veterans Affairs Medical Center, San Diego, California, USA  author email corresponding author email
Respiratory Research 2002,
3:19doi:10.1186/rr168 Abstract
Pulmonary surfactant is a surface active material composed of both lipids and proteins that is produced by alveolar type II pneumocytes. Abnormalities of surfactant in the immature lung or in the acutely inflamed mature lung are well described. However, in a variety of subacute diseases of the mature lung, abnormalities of lung surfactant may also be of importance. These diseases include chronic obstructive pulmonary disease, asthma, cystic fibrosis, interstitial lung disease, pneumonia, and alveolar proteinosis. Understanding of the mechanisms that disturb the lung surfactant system may lead to novel rational therapies for these diseases. | 
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