Increased mDCs in BAL and blood in sarcoidosis. Proportions and numbers of mDCs and pDCs in BAL, Macrophage (M-)depleted BAL and peripheral blood from sarcoidosis patients and healthy controls. Using 9-color flowcytometry, the proportion of mDCs (low autofluorescent, lineage mix negative, HLA-DR+, CD11c+ cells) and pDCs (low autofluorescent, lineage mix negative, HLA-DR+, CD11c-, CD123+ cells) was determined of total BAL cells (A), Macrophage (M-)depleted BAL cells (B), and PBMCs from peripheral blood (C). The number of mDCs and pDCs was calculated as a proportion of total counted BAL cells and PBMCs. Each symbol represents an individual patient or control; lines indicate medians. * p < 0.05; ** p < 0.01.
Berge et al. Respiratory Research 2012 13:33 doi:10.1186/1465-9921-13-33