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COPD association and repeatability of blood biomarkers in the ECLIPSE cohort

Jennifer A Dickens1†, Bruce E Miller2†, Lisa D Edwards3, Edwin K Silverman4, David A Lomas1*†, Ruth Tal-Singer2† and the Evaluation of COPD Longitudinally to Identify Surrogate Endpoints (ECLIPSE) study investigators

  • * Corresponding author: David A Lomas dal16@cam.ac.uk

  • † Equal contributors

1 Department of Medicine, University of Cambridge, Cambridge Institute for Medical Research, Cambridge, UK

2 GlaxoSmithKline, King of Prussia, PA, USA

3 GlaxoSmithKline, Research Triangle Park, NC, USA

4 The Channing Laboratory and Pulmonary and Critical Care Division, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA

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Respiratory Research 2011, 12:146 doi:10.1186/1465-9921-12-146

Published: 4 November 2011

Additional files

Additional file 1:

Additional Table 1. Biomarker Assay Performance Information. Intra- and Inter-assay variability of biomarker assays.

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Additional file 2:

Additional Table 2. Biomarker results at 3 months for COPD subjects with an exacerbation within 30 days of the study visit and COPD subjects with no exacerbations or resolved exacerbations. Results for the biomarkers not shown in Table 4 in the main manuscript.

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Additional file 3:

Additional Figure 3. Bland Altman plots and frequency histograms of differences between baseline and 3-month results illustrating biomarker variability. Results for the biomarkers not shown in Figure 3 within the main manuscript.

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