Table 1

Characteristics of subjects

Normal

Non-Severe asthma

Severe asthma


n

14

12

11

Age (yr)

21 ± 0.4

43 ± 3

47 ± 3

Atopy

0/14

11/12

9/11

M/F

12/2

7/5

4/7

FEV1 (% Predicted)

98 ± 3

85 ± 3

58 ± 6*

PC20 (mg/ml)

>16

5.73 ± 2.7

0.64 ± 0.14*

Inhaled corticosteroid

BDP equivalent (μg/day)

0

527 ± 239

(n = 6)

2400 ± 414*

(n = 11)

Oral prednisolone (mg/day)

0

0

19.1 ± 3.2

(n = 6)

Total BAL Cells

(× 106)

9.19 ± 1.4

8.36 ± 0.8

6.1 ± 0.99

BAL-Macs (×106)

9.02 ± 1.32

8.17 ± 0.76

5.81 ± 1.00

BAL-Neu (×106)

0.1 ± 0.03

0.063 ± 0.016

0.15 ± 0.03

BAL-Eos (×106)

0.018 ± 0.012

0.026 ± 0.012

0.07 ± 0.03

BAL-Mac (%)

97.9 ± 0.5

97.8 ± 0.4

92.9 ± 1.5**

BAL-Neu (%)

1.03 ± 0.3

0.8 ± 0.2

3 ± 0.7*

BAL-Eos (%)

0.21 ± 0.09

0.29 ± 0.14

1.4 ± 0.55*


Abbreviations: M = Male; F = Female; BAL = Bronchoalveolar lavage; BDP = Beclomethasone dipropionate; Neu = neutrophils; Eos = eosinophils; Mac = macrophage. Data shown as mean ± SEM. *p < 0.05; **p < 0.01 compared to non-severe asthma.

Bhavsar et al. Respiratory Research 2010 11:71   doi:10.1186/1465-9921-11-71

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