Individual levels of LTB4 measured after LPS in the absence or presence of dexamethasone (10-6 M) from alveolar macrophages stimulated by LPS in normal subjects (n = 9), non-severe asthmatics (n = 9) and severe asthmatics (n = 8). In the asthmatic groups, closed symbols indicate those on regular treatment with inhaled and/or oral corticosteroids. Data shown as mean ± SEM. Panel C. Mean degree of suppressibility of LXA4 and LTB4 release by dexamethasone. Data is expressed as % of LXA4 or LTB4 release after exposure to LPS (level after LPS minus basal level) and shown as mean ± SEM.
Bhavsar et al. Respiratory Research 2010 11:71 doi:10.1186/1465-9921-11-71